A mendelian Randomization is a new tool we have in understanding risk vs bias, confounding, or other relationships. We can't do a randomized clinical trial on whether obesity causes heart attacks. We can't "make" people obese at random, and we couldn't blind them or their docs even if we could. So how will we know whether obesity causes heart attacks or something else causes both? The same question comes up with hsCRP, one of the tests for CV inflammation. Mendelian Randomization helps us understand. Mendelian randomization was first mentioned in the following article: https://pubmed.ncbi.nlm.nih.gov/2869248/ But it's attributed to Gray & Wheatley a few years later: https://pubmed.ncbi.nlm.nih.gov/1855097/ Obesity was found to be causative of heart attacks in this study: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2714500
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