The NIA (National Institute of Aging) and AA (Alzheimer's Association) recently formed another policy group. The purpose is to include the biomarkers and new biological models in research and disease development. Recognized biomarkers include beta-amyloid and tau. It's recognized now that these happen 20 years earlier than dementia. Comorbidities or related diseases include PART (Primary Age-Related Tauopathy), ARTAG (Age-Related Tau Astroglipathy), and CART (Cerebral Age-Related TDP-43 with Sclerosis)( also known as hippocampal sclerosis).
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