Dr Ford Brewer - PrevMed

Mitochondria & Aging - FORD BREWER

Episode Summary

WARNING -This article is for science geeks. It covers a scientific review article in 2018 on the role of mitochondria in aging. The Free Radical Theory was actually first published in 1957. It shows how oxidation provides the power of mitochondria. But the resulting Free Oxygen Radicals cause mtDNA damage and decrease mitochondrial function and mitogenesis(building new mitochondria). More recent evidence demonstrates mitohormesis. That's the fact that lower doses of poisons end up prolonging life by causing an adaptive change in the mitochondria. Mitohormesis is still a work in progress. But we know how to improve mitochondrial function. Exercise (HIIT) and calorie restriction/fasting. https://www.mdpi.com/2073-4425/9/1/22/htm#B3-genes-09-00022 https://academic.oup.com/geronj/article-abstract/11/3/298/616585?redirectedFrom=fulltext https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423095/#R32

Episode Notes

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