Dr Ford Brewer - PrevMed

Lp-PLA2 Tests for Heart Attack Risk - ELISA Test vs. Activity Assay - FORD BREWER MD MPH

Episode Summary

A viewer—Patrick Nabors—was confused about the standard limits of the PLAC test. Well, different limits do exist, as there are different kinds of PLAC tests. In this video, I will compare these two types: the ELISA test vs. the activity assay. What is PLAC, by the way? PLAC is an inflammation test (along with MACR, MPO, and HsCRP). It tests for Lp-PLA2, an enzyme that's released by macrophages or foam cells. Lp-PLA2 stands for "lipoprotein-associated phospholipase A2", and it's associated with HDL and LDL particles. ELISA is the older PLAC test; however, ELISA appears to have problems in measuring the amount linked to lipoproteins and lipopolysaccharides. On the other hand, the newer activity assay appears to have some technical lab advantages as well as stability.

Episode Notes

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